As far as when the "effects" start to kick in it seeems to vary. The 1st 4 weeks of Rads and 1 chemo I was doing almost everything I was doing before, even went jet skiing. After 2nd Chemo dose started to slow down but still drove back and forth, worked some and made myself stay semi active (short walks around the block). The last 2 weeks of Rads and last Chemo and 2 weeks after were not a lot of fun. But drank water , Ensure and got through it.

I cannot comment on Peg as I did not have one.

Bill Van Horn-53 ex-smoker, social drinker, Biopsy 8/24, Diagnosed 8/30/07 BOT T2N2-B MX Stage IV. Started treatments 10/1/07. IMRT 35 x, Cisplatin - 3 cycles - completed treatment 11/16/07. CT Scans on 1/15/08 all clear Selective neck dissection 1/28/08. All nodes clear.