Sorry for the news. Chemo and radiation resistance is thought to be caused by many factors like field cancerization, cancer repolulation, angiogeneses, anemia, hypoxia, drug resistance, genes, and is a concern with my recurrences, which prior treatments were ineffective. I don't know what clinical trial they are speaking of, but maybe should be different that what was already given, and more of a targeted therapy. I had HD-IORT, high dose rate Intraoperative radiation therapy, which is similar to Brachytherapy, and can be used for recurrences in previously irridated tissue in the oropharynx, mouth, elsewhere, and radiation, after resection, possibly flap, is radiation directly on or in the tumor, in addition too, additional EBRT after surgery, with a targeted drug, in my case, and or chemo. This is an aggressive treatment, and done only in a few places. There are chemo or targeted therapies that are injected directly into the tumor during surgety, but I did not have this done. Good luck with everything.