Haven't done it yet with these guys, but all my previous rats were up for a game (some even invented some, like RatBertha with Jeanne (my ex-wife) and her chair in the morning) as long as they were fully awake -- However, I try to make a point of giving them a treat once they are back in the cage (sometimes makes it easier to get them back in the cage when they are exploratory females) -- It's very frustrating right now to not be able to make any "food" noises to signal that treats are on deck!

RatBertha was the best game rat so far -- If I ran up and down the stairs, she would bound along beside me -- When Jeanne gave me a tiny key-chain pump squirt gun for Christmas one year, as the little kid I am, I started squirting RatBertha with it and she started ducking around corners and then peeking back -- We would chase each other around the house for a while -- She was also very content to go out in public on my shoulder, surveying her domain like a Pasha in one of those fancy elephant-back carriers -- I had her wearing a red scrunchy around her neck one Christmas season as we all toured some outdoor markets.