Seana,
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When my mother was on prednisone she was very irritable. In the States, here, the phrase 'Roid Rage (for steRoid Rage) is used to describe the reaction to drugs like dex. You are definately not alone with this difficulty. If the rest of A's family can keep an eye on him while he is being irrational, it might be best. Keep his doctors up to date on all that is going on.

As care giver to care giver, I wish I could give you a hug. It is hard enough to bear the worry of the disease and treatment, but to add in the emotional pain of the irrationality and rejection must be horrible. Please, please, kept telling yourself it is the dex talking, not your husband. You will have him back in the near future, but I am so sorry this happened in the first place. Thoughts and prayers for you and A heading from Ohio to the other side of the world.
Maria