[quote]My husband is going for a CT (with contrast) chest scan today. Since its been 9 weeks since the PET/CT (non contrast) maybe we will get an idea of how this thing is behaving. [/quote]This is the best situation. Wait a couple days and read the CT impression and go from there. If it has grown you know something needs to be done, from my understanding it is usually palliative, unfortunately. Since they were stained p-16+ then you know they are neoplastic so that should be no surprise. I guess the chances of it shrinking on its own don't seem very realist and even it shows the same size then what to do, right? Most likely chemo anyway. Why they don't do surgery in these situations is something I do not understand as yet.

FYI - I have had two nonspecific spots on my lungs and am in a holding pattern. I am HPV p16+ too. The first PET from Dec 2012 showed them. The latest CT done in March 2013 showed them, no change. During that time I went through three rounds of induction chemo TPF (Taxotere, CisPlatin, 5FU). The primary BOT and regional lymph nodes shrunk away completely and the final impression was "near or complete response", so the rational is if these spots were neoplastic and p16+, they should have at least shrunk up some; they were small less than 1.2cm with SUV less than 2. CT done after these rounds and the spots shows unchanged, so the logic is if it was neoplastic and p16+, in other words, the primary had metastasized to the lungs, then the response should have shown these to reduce or disappear, which did not happen.

So this leaves the diagnosis on these things with pulmonary which I saw several times and they could not put their determine anything other unless going in and doing biopsy but since they agreed if it was same cancer then it should have responded so it must be something else. So the question became how critical is it to know if it is inflammatory and or scarring and it was generally agreed to just park this for a bit and wait for the next PET and/or CT scan to see if anything changes. I agree in this situation it does not seem critical to take any more steps right now to further study these two spots. It remains a bit unsettling all the same.

Post back the report for sure. don