There are multiple types of needle biopsies.

During a needle biopsy, your doctor uses a special needle to extract cells from a suspicious area. A needle biopsy is often used on tumors that your doctor can feel through your skin, such as suspicious, enlarged lymph nodes. When combined with an imaging procedure, such as X-ray, needle biopsy can be used to collect cells from a suspicious area that can't be felt through the skin. Often they will take more than one sample.

Needle biopsy procedures include:

Fine-needle aspiration. (FNA) During fine-needle aspiration, a long, thin needle is inserted into the suspicious area. A syringe is used to draw out fluid and cells for analysis.

Core needle biopsy. A larger needle with a cutting tip is used during core needle biopsy to draw a column of tissue out of a suspicious area.

Vacuum-assisted biopsy. During vacuum-assisted biopsy, a suction device increases the amount of fluid and cells that is extracted through the needle. This can reduce the number of times the needle must be inserted to collect an adequate sample.

Image-guided biopsy. Image-guided biopsy combines an imaging procedure, such as X-ray, computerized tomography (CT) or ultrasound, with a needle biopsy. Image-guided biopsy allows your doctor to access suspicious areas that can't be felt through the skin, such as abnormalities on the liver, lung or prostate. Using real-time images, your doctor can make sure the needle reaches the correct spot.

You'll receive a local anesthetic to numb the area being biopsied in order to minimize the pain.