Hi Wendy - What a rough road the two of you have been on! I do hope that the next clinical trial your husband starts soon will be the one that changes things for the better. As Donna says, i t is important to take care of You, too - and let friends and family share some of the tasks. People do want to help but often, they don't know how unless you tell them. Perhaps you could make a list of the day-to-day things that need doing or things that your husband would like that he hesitates to ask for. Whenever someone asks how they can help, you can show them the list so they can pick something they feel comfortable doing and it can make someone who cares about you feel really good to be helping out in some way. Check back here often and let us know how things are going.