A real comparison between cisplatin and carboplatin is needed, the question is will this ever be done (for H&N cancer) and who would pay for it. BTW: In order to get a drug approved a company does not have to prove that it is more efficient than an existing drug... oh no it just has to be better that nothing!
cisplating is an ancient drug that has been discoverend centuries ago. (FDA approved in the 70s). Carboplatin is the "new kid" on the block (FDA approved in the late 80s). Chemically they are very similar.
Many MO are more comfortable with cisplatin because it has been around longer and therefore there is more data. What is interesting is that when they switch you from cisplating to carboplatin they usually also tell you that it is just as effective!!
It would be nice if a real side to side comparison existed. If anyone is aware of a direct comparison.... please post.

Trev if you are worried about side effects you have to consider the amount of drug that is given. In most of the above post that info is missing, but you can assume that in a weekly setting the concentration is much lower than in a 3 week cycle and so are the side effects.

M