My husband has SCC of the head and neck - just diagnosed recently - starting treatments tomorrow - radiation and chemotherapy. They have not found a primary tumor site despite 2 surgeries, a CT scan, PET scan, and MRI. He has a large lump on the left side of his neck (above clavicle). I am scared that the radiation of all areas as opposed to targeting a primary site will be devastating and eliminate any quality of life. Has anyone else gone through radiation treatments of the head and neck with unknown primary and can you tell me what he can expect, and more importantly, if he should know all of the details of what may happen? The doctors only say he will have dry mouth and mouth sores and possibly a problem with his jaw bone, but won't say anything else. I am very confused and want to think that he should just have the area that has cancer (the lymph nodes in his neck) radiated and leave the rest alone. If the primary isn't showing up, then why treat everything? I am told that it is very unusual to not find the primary site. Is there anyone who has experienced this who can give me some opinions? Thank you very much.