Nimorazole is basically an antimicobial, to treat cettain infections, and is not a chemo, it was used as a radiosensitizer in the study.
Also, for small T1 or T2 tumors, surgery or radiation is often done alone, wether
HPV postive or negative, and some doctors feel it's unnecessary to give chemo or even chemoradiation if surgery is done, and is often the preferred method.
There is a radomozed study with radiation with and without Cetuximad (
Erbitux), which is a monoclonal antibody, in patients who had surgery for locallly advanced Head and Neck cancer. One of the secondary objectives, is to anyalze
HPV in subset of oropharyngeal patients, and to perform exploratory anyalsis of the impact of
HPV in DFS and OS.
A patient's condition, also factors in if chemo will be given with radiation, even with being
HPV positive. I was never tested for
HPV in 2009, and most likly it is being a non-smoker, casual drinker, at 48, and my oncologist would not give me chemo with radiation in 2010 after a recurrence,due to my body, not being able to handle it, saying it would kill me.
There is more talks about treatment de-esculation being
HPV positive with less radiation, less chemo, being it is so responsive.
These are just some examples that chemo therapy is not always given with radiation, including with
HPV positive patients. Future studies, and long term results will prove it's effacy.