After rereading OP, I am not sure what he means by "no chemo". I can understand this if it means no induction chemo either sequential then CRT, slit, or post CRT. If he means no chemo as part of radiation, that does not sound right. The Lassen study at DAHANCA even uses a "Chemo" for the standard reason of making the rad work better.

[quote]Lassen and her colleagues investigated the outcomes of 181 patients on the Danish Head and Neck Cancer Group (DAHANCA) database who were treated between 1992 and 2005 for advanced oropharyngeal cancer�cancer that has spread from the primary site to lymph nodes and beyond. The patients received accelerated radiotherapy (six fractions of radiation over five days in order to reduce the overall length of treatment) together with Nimorazole, an agent that acts as a radiotherapy sensitiser, making cancer cells more receptive to the effects of radiation. No chemotherapy was given. Samples of tumour tissue were analysed to establish HPV status. [/quote]
Seems like this drug is used because of accellerated deliver of rads. who knows, getting way over my med tech knowledge. :-)
[quote]Abstract
BACKGROUND AND PURPOSE:
Causes of failure of radiotherapy in squamous cell carcinoma of the head and neck probably include repopulation and hypoxia. Very accelerated schedules such as continuous hyperfractionated accelerated radiation therapy (CHART) overcome the repopulation problem but allow limited time for reoxygenation, so a hypoxic-cell sensitizer may be especially beneficial. Nimorazole is the only such agent to have shown a significant effect in a randomized controlled trial in head and neck cancer. Accordingly we studied the combination of CHART and nimorazole.
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