Fluoride is forever, ten minutes sounds about right, at night just before going to bed. Any other time and you are drinking water all day and rinsing it off your teeth too soon. I use the Biotene toothpaste because there is some validity in their scientific claims that enzyme replacement helps prevent caries and periodontal disease, plus it has fluoride and calcium in it. If you use a Rx strength fluoride toothpaste, Prevident 5000 from Colgate is one, you can substitute that for your trays a couple of nights a week, which I do because to this day the fluoride is still one nasty thing to put in your mouth!! Afterwards you should not rinse or drink for 15 to 30 min..... I seldom make it to the 30 min mark. By the by for those of you that are caregivers and may be taking antidepressants, please note that selective serotonin reuptake inhibitors (which they all are) cause mild xerostomia, as do drugs for diabetes and many other conditions. While not an acute form of xerostomia, Biotene toothpaste will help prevent problems while you are on the drugs.

Brian, stage 4 oral cancer survivor. OCF Founder and Director. The first responsibility of a leader is to define reality. The last is to say thank you. In between, the leader is a servant.