I think this will help you to better understand the entire OC process, including biopsies. Best thing I can tell you is to ask your doctors. I wouldnt know if the lymph nodes would appear different depending on if the cancer moved to them or if it originated there. I would think finding the primary tumor would be very important in helping the doctors to know what areas to focus on with treatments so they can completely eliminate the cancer. If the cancer has gone into the lymph nodes, it had to come from somewhere unless it started in the lymph nodes. But that info is something I wouldnt know. As someone who does not have a medical degree, or any medical training these things are a bit too in depth for me. Your doctor with all their years of education, training, etc will have to explain this type of thing to you.

Main OCF Site, Understanding section