Thank you Gloria and Vegan.

Vegan, to your question, while I was participating in my trial of GDC-0980 they did sample and study my tumour and concluded it may be a candidate for the ATR-inhibitor trial drug, but alas the version of that that I have ready access to here (there are multiples) is only in very early Stage 1 trial, so if I could get in on it, it would be a very low 'tolerability level' stage of study.

The approach regarding chemo as I understand it is my cancer has already 'survived' the logical chemos to try, so now they're trying what's left. It's not rocket science, I'm afraid. Mine is a second recurrence. There are not enough statistics to apply to my case to be 'scientific' about it. My cancer has shrugged off Cisplatin twice now (that's the Big Gun, I gather).

This combo I'm on now is my very senior-level Oncologist's best guess at what might work, or at least help, while other stuff is getting figured out.

As I understand it, this is the state of the art in my case.

Not a very satisfying answer, no doubt, and if anyone knows better/otherwise I'm all ears.

Mine is metastatic Squamous Cell Carcinoma, positive for the HPV P16 markers (the GDC trial targeted that), with the ATR mutation (meaning the cancer cells can only split/multiply via the ATR pathway.

Once I've survived this second chemo (fingers crossed, and planning to drug the heck out of my symptoms this time), they do a CT and see what they can see. And then we discuss.

At the moment I'm extremely anaemic, I rather wish I had known this sooner and could have had a transfusion sooner. I need to complain more, it would seem. Live and learn, right?

Good night all, from London England (still part of Scotland)

-Seth