DuffyMo

I'm not going to repeat everything in the thread that DavidCPA mentioned, especially since it sounds like you already read it.
If not, here is the direct link Erbitux & HPV do not play well together
In rereading those posts from last year, I realized that I should have added in that at first my wife and I were ecstatic about choosing Erbitux. Just like one poster noted, the Erbitux shrank my two cancerous lymph nodes like magic, much much faster than anyone expected. Plus the salvage surgery after the cancer came back showed that the combo of radiation & Erbitux not only shrank the lmyph nodes but actually killed all the cancer cells - they were totally necrotic according to the pathology report.
But that's the kicker: the Erbitux did not do it's magic on the primary base of tongue tumor. Platinum based chemo like Cisplatin or Carboplatin does crush primary tumors (in conjunction with radiation) and more importantly also works well if there is Perineural Involvement (PNI). Or so I was told by my MO when we did our second round of chemo.
It's a pretty smart board here and so far nobody has posted any reliable studies contradicting the studies I cited and relied upon in my screed against Erbitux.
Again, just because it did not work for me, does not mean it would not work for your husband, but without any studies showing that Erbitux plays well with HPV+, it's a gamble.
Actually the Erbitux complications were far worse for me than the platinum based Carboplatin so my personal experience belies the advertising that Erbitux is "easier or less toxic".

But maybe there will be OCF members with Base of tongue cancer for whom Erbitux worked not only on the lymph nodes but also for the BOT tumor.
Charm