| Joined: Jul 2012 Posts: 3,267 Likes: 4 Patient Advocate (old timer, 2000 posts) | OP Patient Advocate (old timer, 2000 posts) Joined: Jul 2012 Posts: 3,267 Likes: 4 | The FDA recently announced labeling changes to warn of risk for possibly permanent nerve damage from antbacterial fluoroquinolone drugs taken by mouth or by injection shortly after taking. This may be the cause or worsened the effects of the severe neuropthy I have, which I didn't have before treatment in 2009, and even noiced the last two weeks it worsened after taking antibiotics for some teeth issues from radiation, but mine is not on their list, Amoxicillin and Clavulanate Potassium, yet. I did take Cipro back in May after surgery, and extensivly in 2010 for C-Diff. They include: Avelox Cipro Cipro IV Cipro XR Factive Levaquin Noroxin http://www.fda.gov/Drugs/DrugSafety/ucm365050.htm
10/09 T1N2bM0 Tonsil 11/09 Taxo Cisp 5-FU, 6 Months Hosp 01/11 35 IMRT 70Gy 7 Wks 06/11 30 HBO 08/11 RND PNI 06/12 SND PNI LVI 08/12 RND Pec Flap IORT 12 Gy 10/12 25 IMRT 50Gy 6 Wks Taxo Erbitux 10/13 SND 10/13 TBO/Angiograph 10/13 RND Carotid Remove IORT 10Gy PNI 12/13 25 Protons 50Gy 6 Wks Carbo 11/14 All Teeth Extract 30 HBO 03/15 Sequestromy Buccal Flap ORN 09/16 Mandibulectomy Fib Flap Sternotomy 04/17 Regraft hypergranulation Donor Site 06/17 Heart Attack Stent 02/19 Finally Cancer Free Took 10 yrs
| | | | Joined: Dec 2003 Posts: 2,606 Likes: 2 Patient Advocate (old timer, 2000 posts) | Patient Advocate (old timer, 2000 posts) Joined: Dec 2003 Posts: 2,606 Likes: 2 | I think there should be black box warnings on this class of drugs for anyone going through chemo or radiation. Most neurological or neuromuscular issues will be exacerbated. Musculoskeletal issues as well.
I think any MRI's with contrast prior to 2007 or so are highly suspect for fibrosis and vascular constriction and resultant kidney, liver, lung or heart failure. It was believed all fibrosis began with the skin but in 2003 post mortems were performed and the link to organs was established. Vascular constriction with electrolyte imbalance, specifically potassium will cause temporary and potentially permanent peripheral neuropathies. GFR should always be checked prior to using GBCA's. I don't see it being done but I know someone has to be reviewing lab histories before the MRI. The results can be fibrosis of any connective tissue in the body and even broken bones due to weaker connective tissue.
SCC Stage IV, BOT, T2N2bM0 Cisplatin/5FU x 3, 40 days radiation Diagnosis 07/21/03 tx completed 10/08/03 Post Radiation Lower Motor Neuron Syndrome 3/08. Cervical Spinal Stenosis 01/11 Cervical Myelitis 09/12 Thoracic Paraplegia 10/12 Dysautonomia 11/12 Hospice care 09/12-01/13. COPD 01/14 Intermittent CHF 6/15 Feeding tube NPO 03/16 VFI 12/2016 ORN 12/2017 Cardiac Event 06/2018 Bilateral VFI 01/2021 Thoracotomy Bilobectomy 01/2022 Bilateral VFI 05/2022 Total Laryngectomy 01/2023
| | | | Joined: Jul 2012 Posts: 3,267 Likes: 4 Patient Advocate (old timer, 2000 posts) | OP Patient Advocate (old timer, 2000 posts) Joined: Jul 2012 Posts: 3,267 Likes: 4 | Interesting, Ed. I check, and most my doctors know my creatine is high or GFR is low, and bring it to their attention, if not. As for the diagnostic center, labs were never checked, I think, having only had Two MRI's, and others were CT, which contrast I can't have and PET/CT. They do have you fill out a questionnaire.
10/09 T1N2bM0 Tonsil 11/09 Taxo Cisp 5-FU, 6 Months Hosp 01/11 35 IMRT 70Gy 7 Wks 06/11 30 HBO 08/11 RND PNI 06/12 SND PNI LVI 08/12 RND Pec Flap IORT 12 Gy 10/12 25 IMRT 50Gy 6 Wks Taxo Erbitux 10/13 SND 10/13 TBO/Angiograph 10/13 RND Carotid Remove IORT 10Gy PNI 12/13 25 Protons 50Gy 6 Wks Carbo 11/14 All Teeth Extract 30 HBO 03/15 Sequestromy Buccal Flap ORN 09/16 Mandibulectomy Fib Flap Sternotomy 04/17 Regraft hypergranulation Donor Site 06/17 Heart Attack Stent 02/19 Finally Cancer Free Took 10 yrs
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