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I'm back into research mode, and anxiety mode, as my husband had a biopsy of a skin lesion on his leg come back positive for SCC.

The following is from Mayo skin cancer online:
HPV - This group of viruses has more than 100 strains, about a third of which are sexually transmitted. Some of the viruses cause genital warts; others can lead to cancer of the vagina, cervix or penis. Now, researchers think that infection with certain types of HPV may also play a role in the development of squamous cell skin cancers.

Anyone aware of a connection to skin cancers? Notice above does not mention Oral Cancer.

My husband has now had three types of cancers in 3 years.
2007 prostate cancer (adenocarcinoma), 2008 BOT (SCC), 2009 skin (SCC)
Lottie


CG to husband, dx @ age 65, nonsmoker/social drinker. Dx 5/08 SCC Stage IV, BOT T1N2aM0. 33 IMRT - completed 9/12/08. Induction Chemo (Cisplatin, Taxotere & 5FU), plus concurrent Cisplatin.
1/09 PEG removed; 5/09 neg PET/CT; 5/10 PET/CT NED
Dental extraction & HBOT 2013; ORN 2014; Debridement/Tissue Transfer & HBOT 2016
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Hi Lottie - Don't know if this will help you, but my husband has had both cancers all over and a while back, had a pre-melanoma (dr. didn't know whether it would have actually turned to a melanoma or not) on his leg removed. He has had both basal cell and SCC removed from his face and skin. This is besides his 3 oral SCCs. Now they found a small basal cell on his external nose which he will have Mohs surgery on next week. He doesn't have HPV. Hope this helps. Some seem to be more susceptible to skin cancers than others, unfortunately.


Husband: 3 SCC gum and cheek cancers 2002, 2005, 2006: surgery only. Scans clear after removal of small, well differentiated, non-invasive cancers. No radiation. 4th SCC lip diagnosed 4/13/07 - in situ, removed in biopsy. More lip removed 2/8/08 - dysplasia. 2 Biopsies 3/17/09 no cancer (lichenoids)
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SCC is caused by more things than HPV

Solar radiation induced SCC, BCC, on the face (and top of head for those of us without so much up there anymore to protect it) are very common, removed easily, and not wildly invasive like oral SCC

I have yet to see another web page that has all the information on HPV that has accurate information on it. As the primary person that works with Dr. Maura Gillison keeping OCF's HPV page current, I am not totally surprised by this, because the information is changing rapidly as new information reveals itself. I have made edits in our own page, (without significant additions of new content) that change numbers, percentages, and the "authority/tone" with which we comment on certain aspects of it all as reinforcing material makes itself apparent.


Brian, stage 4 oral cancer survivor. OCF Founder and Director. The first responsibility of a leader is to define reality. The last is to say thank you. In between, the leader is a servant.
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The good news is that every day we learn more about HPV.

The bad news is that every day we learn more about HPV.

Lottie, did they test either SCC site cells for HPV?


David

Age 58 at Dx, HPV16+ SCC, Stage IV BOT+2 nodes, non smoker, casual drinker, exercise nut, Cisplatin x 3 & concurrent IMRT x 35,(70 Gy), no surgery, no Peg, Tx at Moffitt over Aug 06. Jun 07, back to riding my bike 100 miles a wk. Now doing 12 Spin classes and 60 outdoor miles per wk. Nov 13 completed Hilly Century ride for Cancer, 104 miles, 1st Place in my age group. Apr 2014 & 15, Spun for 9 straight hrs to raise $$ for YMCA's Livestrong Program. Certified Spin Instructor Jun 2014.
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Brian,
I should have made clear that HPV was listed as ONE possible cause of skin cancer.
Sun exposure, therapeutic rad, chemical toxins, immunosuppressant drug, etc. are also listed.

Does that mean that HPV can be systemic and manifest as skin cancer? I have never read that and will look into it further.

Lostpassword, It does help to hear from others - thank you.



CG to husband, dx @ age 65, nonsmoker/social drinker. Dx 5/08 SCC Stage IV, BOT T1N2aM0. 33 IMRT - completed 9/12/08. Induction Chemo (Cisplatin, Taxotere & 5FU), plus concurrent Cisplatin.
1/09 PEG removed; 5/09 neg PET/CT; 5/10 PET/CT NED
Dental extraction & HBOT 2013; ORN 2014; Debridement/Tissue Transfer & HBOT 2016
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My HPV expert at Moffitt says:

Recall that there are over 100 different types of HPV viruses. Around 40 infect the mucosal surfaces of the anogenital tract and the oral, oropharynx. There are as many different HPV types that infect the cutaneous skin. My research group and others are investigating whether these types of HPV cause skin cancer � specifically non-melanoma skin cancer. The published literature to date suggest that YES, certain types of these so called cutaneous HPV types are indeed associated with non-melanoma skin cancer. Until we see more published studies confirming this association we say that HPV possibly causes skin cancer.





David

Age 58 at Dx, HPV16+ SCC, Stage IV BOT+2 nodes, non smoker, casual drinker, exercise nut, Cisplatin x 3 & concurrent IMRT x 35,(70 Gy), no surgery, no Peg, Tx at Moffitt over Aug 06. Jun 07, back to riding my bike 100 miles a wk. Now doing 12 Spin classes and 60 outdoor miles per wk. Nov 13 completed Hilly Century ride for Cancer, 104 miles, 1st Place in my age group. Apr 2014 & 15, Spun for 9 straight hrs to raise $$ for YMCA's Livestrong Program. Certified Spin Instructor Jun 2014.
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David, Thank you for keeping us up to date about information from HPV expert at Moffitt. Your statement about good news/bad news regarding HPV is so true.

My husband did not have BOT tumor tested for HPV. His MO does not routinely send for HPV testing, unless the patient insists. My husband did not insist.

He is scheduled for skin lesion excision in Dec and I'll see what the dermatologist has to say.

Meanwhile - another clear PET! Lottie


CG to husband, dx @ age 65, nonsmoker/social drinker. Dx 5/08 SCC Stage IV, BOT T1N2aM0. 33 IMRT - completed 9/12/08. Induction Chemo (Cisplatin, Taxotere & 5FU), plus concurrent Cisplatin.
1/09 PEG removed; 5/09 neg PET/CT; 5/10 PET/CT NED
Dental extraction & HBOT 2013; ORN 2014; Debridement/Tissue Transfer & HBOT 2016

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