I think that's dependent on how well your hubby takes the treatment. Caretakers may need to be around from week 4-9 (I know his treatment will run for 6.5 to 7 weeks but the two weeks following radiation are actually worse. If he stays well hydrated and maintain his weight within reasonable standards, he may need 2-3 months off - likely from week 3-4 until he's feeling okay - possibly a month after treatment has finished (I'm being optimistic here) some people manage to work through it is they are independent workers and can do desk type work at home at their own pace. Mostly the person feels tired if they have trouble with chemo there may be varying degrees of nausea. There is also the potential for skin burns on his neck etc.... So that's a difficult question. I drove myself daily to treatment but not everyone can. I was very blessed that even though it was horrible. I was okay. Hugs and best of luck,