 Patient Advocate (old timer, 2000 posts)
Joined: Dec 2003 Posts: 2,606 Likes: 2 | I really hate mentioning this but ORN can occur anywhere, including the spine, or so I've been told as the vertebrae stopped producing marrow. It started with C-3 and the last MRI showed C-1 to C-7. The only bisphosphonates that have ORN risk are the long term injectibles. The oral versions are actually used to treat ORN of the mandible. It makes no sense to me that something used to treat ORN can cause it. Some studies I looked at were using people with radiated mandibles and the rate of ORN was the same as people not taking bisphosphonates, around 10%.
One of the reasons the mandible has such a high rate is the size and density of the bone.
SCC Stage IV, BOT, T2N2bM0
Cisplatin/5FU x 3, 40 days radiation
Diagnosis 07/21/03 tx completed 10/08/03
Post Radiation Lower Motor Neuron Syndrome 3/08.
Cervical Spinal Stenosis 01/11
Cervical Myelitis 09/12
Thoracic Paraplegia 10/12
Dysautonomia 11/12
Hospice care 09/12-01/13.
COPD 01/14
Intermittent CHF 6/15
Feeding tube NPO 03/16
VFI 12/2016
ORN 12/2017
Cardiac Event 06/2018
Bilateral VFI 01/2021
Thoracotomy Bilobectomy 01/2022
Bilateral VFI 05/2022
Total Laryngectomy 01/2023
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