Apappala - You have already done a super-human caregiving job and certainly do not deserve to be treated this way no matter what the source of your husband's behavior. When my son was in Tx, he was very depressed and seeing a therapist for the depression. At times he was irritable but not to the extent that you and many others have described here. I would definitely mention this to your husband's doctors to see what help they could give him and for you, too. I'm sure others will be along here that can share their experiences and suggestions. Meds can definitely affect behavior. Check his prescription bottles for side effects. One of the meds my son was on plainly said "can cause suicidal thoughts" which I happened to check and told my son who called his doctor but in his case, the doctor felt it did not apply to him. But just talking to the doctor about it, made him feel better. There are many things that can affect behavior, even vitamins so it's best to make sure the doctors know everything that is going into his body (also coming out of his body). Just being constipated can make some people very irritable. Apappala - be sure and take care of you, too. If your own well being is compromised, you won't be give to others what you don't have to give. Stay with us and let us know what is happening.