I had the 3 weekly despite being told it was likely I was cured - this is the protocol for my hospital - I had minor nausea that it -,I did miss the last dose as my WBC count was low and verything was off a week. But I did fine on it - some have a bad time - depends on the person. Is you husband normally sensitive to meds? have health problems? This would b a factor too. One thing I did note you said niversity medical vs private hospital. Your husband should be treated at a comprehensive cancer center. Good luck...