My husband Ron was like DavidCPA, he looked pretty skeletal the first couple of year's post treatment. He's 5'11" and went from 190 lbs down to 130 lbs post Tx. He still is on the thin side, 170 lbs but likes it that way. His knees aren't the best so being thin helps his knees. You're brother will be OK its just going to take time. As David said, his body has been through Hell and back.
Hope this helps,
Shelley