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tamvonk Offline OP
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Kris saw the oral surgeon today. His teeth continue to decay and the time has come for some definitive treatment.
HBO is one of our options prior to extraction. However, the oral surgeon mentioned to us that if there is 1 remaining cancer cell, HBO can accelerate growth.
Frankly, if this is so I will not let Kris undertake this.
Does anyone here know if this is so? I can only find conflicting papers/opinions on this.
Thanks in advance for any advice.
Tammy


Caregiver/advocate to Husband Kris age 59@ diagnosis
DX Dec '10 SCC BOT T4aN2bM0 HPV+ve.Cisplatin x3 35 IMRT.
PET 6/11 clear.
R) level 2-4 neck dissection 8/1/11 to remove residual node - necrotic with NED
Feb '12 Ca back.. 3/8/12 total glossectomy/laryngectomy/bilat neck dissection/partial pharyngectomy etc. clear margins. All nodes negative for disease. PEG in.
March 2017 - 5 years disease free. Woohoo!
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I would think the opposite since most cancers prefer a hypoxic environment. Isn't the premise behind hbo to flush O2 into the area to promote healing. The only connection I could see would be that it likely increases metabolism in the area and circulation - and therefore possibly cancer spread. But if there is one cancer cell there then chances are with or without hbo it will grow. There are many here who've had hbo.

Last edited by Cheryld; 07-17-2013 01:40 AM.

Cheryl : Irritation - 2004 BX: 6/2008 : Inflam. BX: 12/10, DX: 12/10 : SCC - LS tongue well dif. T2N1M0. 2/11 hemigloss + recon. : PND - 40 nodes - 39 clear. 3/11 - 5/11 IMRT 33 + cis x2, PEG 3/28/11 - 5/19/11 3 head, 2 chest scans - clear(fingers crossed) HPV-, No smoke, drink, or drugs, Vegan
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Yes, you are correct Tammy.

Cheryl is also right about But if there is one cancer cell there then chances are with or without hbo it will grow.

Cancer loves oxygen and thats what HBO is, pressurized pure oxygen. I dont know exactly where I got this info from, I cant remember reading any studies about it. Im sorry, I wish I had a study to refer you to so you would be able to make a decision.

One thing I do know for certain, ORN can be brutally painful. Plus it will only spread as time goes on if left untreated. This is what our pal EzJim has gone thru over the past couple years. He was not able to do HBO due to other medical issues and HBO is what he needed to do for his bad jaw. Poor guy is in alot of pain for years and I just dont know how he is able to manage it on a daily basis. Recently, Ive had my own ORN issues and surgeries that I havent discussed here. At this time my situation has been corrected.

I would discuss this with any other doctors who are familiar with HBO, like an ENT or the oncology docs.

Best wishes, please let us know how you make out.


Christine
SCC 6/15/07 L chk & by L molar both Stag I, age44
2x cispltn-35 IMRT end 9/27/07
-65 lbs in 2 mo, no caregvr
Clear PET 1/08
4/4/08 recur L chk Stag I
surg 4/16/08 clr marg
215 HBO dives
3/09 teeth out, trismus
7/2/09 recur, Stg IV
8/24/09 trach, ND, mandiblctmy
3wks medicly inducd coma
2 mo xtended hospital stay, ICU & burn unit
PICC line IV antibx 8 mo
10/4/10, 2/14/11 reconst surg
OC 3x in 3 years
very happy to be alive smile
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Posts: 2,606
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A few studies have indicated it can further tumor growth but some studies have shown it actually hinders the angiogenesis process by exerting pressure on the arterioles or capillaries feeding the tumor. One important finding is the HBOT oxygenates the tumor and improves radiotherapy efficacy. I don't know if anyone can clearly say it hurts more than it helps as every person is different as in all other treatment modalities.


SCC Stage IV, BOT, T2N2bM0
Cisplatin/5FU x 3, 40 days radiation
Diagnosis 07/21/03 tx completed 10/08/03
Post Radiation Lower Motor Neuron Syndrome 3/08.
Cervical Spinal Stenosis 01/11
Cervical Myelitis 09/12
Thoracic Paraplegia 10/12
Dysautonomia 11/12
Hospice care 09/12-01/13.
COPD 01/14
Intermittent CHF 6/15
Feeding tube NPO 03/16
VFI 12/2016
ORN 12/2017
Cardiac Event 06/2018
Bilateral VFI 01/2021
Thoracotomy Bilobectomy 01/2022
Bilateral VFI 05/2022
Total Laryngectomy 01/2023
Joined: Jul 2012
Posts: 3,267
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I looked into the hypoxia matter, as Cheyrl mentioned, being anemic, and possibly chemo and and radio resistant due to the multiple recurrnces. The old theory is oxygen feeds cancer, but in agreement with Ed with angeogenesis which makes the tumor, and new area for blood supply, hypoxic, and so cancer thrives in low oxygen they now say. They did studies with HBOT, to inprove hypoxia for radiation, but there was no real benefit in some, some say it did or did not cause any negeative effects, They have a few meds that are or were used that had more benefit, forget names. Oxygen may have an effect during surgery, with the oxygen pressure levels on the tumor itself, which I can't fully explain, understand, that can increase tumor growth, if it's not the correct levels.

I had 30 HBOT treatments for an extraction 4 months after radiation, two months before a recurrence. It's a good question to ask your RO, and the dr with HBOT, who may be a wound management, that may have more knowledge about this.

Last edited by PaulB; 07-17-2013 12:30 PM.

10/09 T1N2bM0 Tonsil
11/09 Taxo Cisp 5-FU, 6 Months Hosp
01/11 35 IMRT 70Gy 7 Wks
06/11 30 HBO
08/11 RND PNI
06/12 SND PNI LVI
08/12 RND Pec Flap IORT 12 Gy
10/12 25 IMRT 50Gy 6 Wks Taxo Erbitux
10/13 SND
10/13 TBO/Angiograph
10/13 RND Carotid Remove IORT 10Gy PNI
12/13 25 Protons 50Gy 6 Wks Carbo
11/14 All Teeth Extract 30 HBO
03/15 Sequestromy Buccal Flap ORN
09/16 Mandibulectomy Fib Flap Sternotomy
04/17 Regraft hypergranulation Donor Site
06/17 Heart Attack Stent
02/19 Finally Cancer Free Took 10 yrs






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Thanks Ed and Paul! This is an interesting subject to me as Ive done way more HBO than I care to count and Ive also had OC 3 times. I was thinking of checking with some wound care specialists that I know but then I thought its kinda like asking a surgeon if they would recommend surgery.

Tammy if you (or anyone else) finds any studies that have been done on this please post for all of us to learn from.

Thanks!


Christine
SCC 6/15/07 L chk & by L molar both Stag I, age44
2x cispltn-35 IMRT end 9/27/07
-65 lbs in 2 mo, no caregvr
Clear PET 1/08
4/4/08 recur L chk Stag I
surg 4/16/08 clr marg
215 HBO dives
3/09 teeth out, trismus
7/2/09 recur, Stg IV
8/24/09 trach, ND, mandiblctmy
3wks medicly inducd coma
2 mo xtended hospital stay, ICU & burn unit
PICC line IV antibx 8 mo
10/4/10, 2/14/11 reconst surg
OC 3x in 3 years
very happy to be alive smile
Joined: Mar 2011
Posts: 1,024
tamvonk Offline OP
"OCF Kiwi Down Under"
Patient Advocate (1000+ posts)
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I have found the following 2 articles this morning. Both state HBO is safe to use when patients have previously been diagnosed with cancer and that HBO does not enhance tumour growth.

http://www.ncbi.nlm.nih.gov/pubmed/23054400

http://www.ncbi.nlm.nih.gov/pubmed/18281803

However Kris is keen on the alternative option we were given.
That is to do Root Canals on the teeth, leave a dressing on and then cap the tooth.
If he was 5 years out I would encourage him to do the HBO, but I still have lingering doubts.
I feel this root canal option will buy him time and then when he gets to the magical dreamed of 5 year mark we can look at HBO.
Thoughts?
Tammy


Caregiver/advocate to Husband Kris age 59@ diagnosis
DX Dec '10 SCC BOT T4aN2bM0 HPV+ve.Cisplatin x3 35 IMRT.
PET 6/11 clear.
R) level 2-4 neck dissection 8/1/11 to remove residual node - necrotic with NED
Feb '12 Ca back.. 3/8/12 total glossectomy/laryngectomy/bilat neck dissection/partial pharyngectomy etc. clear margins. All nodes negative for disease. PEG in.
March 2017 - 5 years disease free. Woohoo!
Joined: Jul 2012
Posts: 3,267
Likes: 1
Patient Advocate (old timer, 2000 posts)
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Thanks for the links. I had several root canals, post treatment, and did not need HBOT either.


10/09 T1N2bM0 Tonsil
11/09 Taxo Cisp 5-FU, 6 Months Hosp
01/11 35 IMRT 70Gy 7 Wks
06/11 30 HBO
08/11 RND PNI
06/12 SND PNI LVI
08/12 RND Pec Flap IORT 12 Gy
10/12 25 IMRT 50Gy 6 Wks Taxo Erbitux
10/13 SND
10/13 TBO/Angiograph
10/13 RND Carotid Remove IORT 10Gy PNI
12/13 25 Protons 50Gy 6 Wks Carbo
11/14 All Teeth Extract 30 HBO
03/15 Sequestromy Buccal Flap ORN
09/16 Mandibulectomy Fib Flap Sternotomy
04/17 Regraft hypergranulation Donor Site
06/17 Heart Attack Stent
02/19 Finally Cancer Free Took 10 yrs






Joined: Dec 2003
Posts: 2,606
Likes: 2
Patient Advocate (old timer, 2000 posts)
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Here is a link with many studies cited if you want to dig deeper.

HBO Study

Last edited by ChristineB; 07-18-2013 11:06 AM. Reason: fix link

SCC Stage IV, BOT, T2N2bM0
Cisplatin/5FU x 3, 40 days radiation
Diagnosis 07/21/03 tx completed 10/08/03
Post Radiation Lower Motor Neuron Syndrome 3/08.
Cervical Spinal Stenosis 01/11
Cervical Myelitis 09/12
Thoracic Paraplegia 10/12
Dysautonomia 11/12
Hospice care 09/12-01/13.
COPD 01/14
Intermittent CHF 6/15
Feeding tube NPO 03/16
VFI 12/2016
ORN 12/2017
Cardiac Event 06/2018
Bilateral VFI 01/2021
Thoracotomy Bilobectomy 01/2022
Bilateral VFI 05/2022
Total Laryngectomy 01/2023
Joined: Jun 2007
Posts: 10,507
Likes: 7
Administrator, Director of Patient Support Services
Patient Advocate (old timer, 2000 posts)
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Administrator, Director of Patient Support Services
Patient Advocate (old timer, 2000 posts)

Joined: Jun 2007
Posts: 10,507
Likes: 7
Thanks for the link!


Christine
SCC 6/15/07 L chk & by L molar both Stag I, age44
2x cispltn-35 IMRT end 9/27/07
-65 lbs in 2 mo, no caregvr
Clear PET 1/08
4/4/08 recur L chk Stag I
surg 4/16/08 clr marg
215 HBO dives
3/09 teeth out, trismus
7/2/09 recur, Stg IV
8/24/09 trach, ND, mandiblctmy
3wks medicly inducd coma
2 mo xtended hospital stay, ICU & burn unit
PICC line IV antibx 8 mo
10/4/10, 2/14/11 reconst surg
OC 3x in 3 years
very happy to be alive smile
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