I have my thoughts on this OC and it seems to be a fairly new disease. So that in itself would eliminate a lot of the causes you listed. People were raised for years on a lot of the things you stated and many years ago. I had one Great grandma live to be 108 and another Great that made 96. My mind has
HPV right at the top of the list because sex was mainly between a husband and wife with no fill ins. The 96 yr old one smoked a corn cob pipe daily. I am 72 and 3/4 and will be 73 in Feb so I have been around for a few years myself.