With the weekly treatment, I did not get the impression that the chemo caused major problems, although it is difficult to separate its effects from those of the radiation. At least I could not time anything specific to the chemo days.. As Christine says watch out for the ringing, it may happen quickly even if given lower doses. I definitely had it already after the first infusion then it went away and got worse after the second time. Then we switched to carboplatin which is not (as) ototoxic.