Hi, Linda: I started two threads on fentanyl recently: One is titled "4 short questions" in Currently in Treatment, the other is "Fentanyl DuHHH" in Medications, Treatment and procedures. I got lots of good info in both of those. I am sure there is much more if you do a search. John has been on liquid Hydrocodone for pain management for 17 mo. It was not really solving the problem. We tried the patch, but he was not able to function on it[he became a space cadet very quickly on 50 mcg.] so we had to stop and go back to hydrocodone. However, we heard from lots of people who could function well on the patch. I think it depends on your tolerance to certain drugs and how strong a dose you need to control pain. If John had been on 100 mcg, he could have gone to the moon without a spaceship. My guess is that it is trial and error. Do some good research and be willing to take it off if your mind gets screwy Amy