There are many factors and too much flouride is an issue as is not enough. My personal regimen is to use foam in disposable flouride (styrofoam) trays once every two weeks. Once a week I brush with Prevident before bed, and three times a day I brush with Biotene which also has lesser amounts of flouride in it. I am 8 years out, have all my teeth and my biggest issue has not been caries but gigival recession around the necks of the teeth. Because I have such a tough time keeping my teeth plaque and calculus free, I see a hygienist every 8 weeks.