All NSAID's can cause stomach upsets, and in extreme cases, as Gray has reported, bleeding. But to balance Gary's point of alarm/danger, it is recommended that they be taken with food, and they are not recommended on the label for anyone who has stomach ulcers or other digestive issues, as Gary's friend certainly had. Long-term use of them can indeed cause stomach bleeding in certain individuals. What Gary has described is not a quick spontaneous condition in most cases. These kinds of reactions to anti-inflammatory drugs occur in individuals who take large doses over prolonged periods of time, or as I said, have existing conditions that preclude their use at all. I am at risk with NSAIDs, and particularly Naprosyn which I took for years as a prescription drug before the FDA deemed it safe enough to sell over the counter without an Rx, as I have chronic inflammatory pain from herniated discs from a helicopter crash. I have been on them for 25 years. (At doses well above what is recommended on the over the counter bottles.) If you have reflux disease, GERD, ulcers etc. these are not for you. Aspirin by the way, a NSAID itself, also causes stomach bleeding in select individuals. While I normally agree with 99% of Gary's posts, I find this one reactionist and out of proportion, without his usual balance for both sides of an issue. Millions of people everyday take anti-inflammatory drugs over the counter in the US. What he is describing is a very out of the ordinary acute reaction, and as my post clearly states, ask your doctor first. But the FDA considers many of them, like Alleve, safe enough to be sold without prescription, right next to the Tylenol, Excedrin etc. in your local drug store. Informed balance in all things is a good idea.......be they medications, or postings.