Yes, it works. For me it was the ONLY med. that worked and unfortunately they didn't prescribe it for me until after I spent a few days vomiting after chemo number one but it really helped me at the end of that and through chemo number two and it helped control the daily nausea I had from the ethyol. I hope you have good prescription drug coverage because it's outrageously expensive otherwise (but, I would say, still worth it if it can help him get through chemo without the days of constant nausea and vomiting).