I would recommend giving it a try. My husband had amifostine, back in the dark ages (four years ago but in the medical field that is a long time) when they gave via IV push. He did have some low blood pressure, nothing major though, and the nausea he was able to control with compazine and then Zofran toward the end. His mouth was pretty dry for awhile post treatment, but four years out he has a pretty good supply of saliva. For about 2 years after radiation he had to have a glass of water to eat anything and he was always holding a bottle wherever he went. This past visit to Dr (four year check up), the Dr was like, "Where is your water bottle?" He said, "don't need it!"
For him, it was worth it.