My husband had radiation for tonsil cancer and he had amifostine prior to each treatment. It was given IV. He tolerated it pretty well. At one point had to switch from nausea pill compazine to zofran (expensive stuff), but made it through all the treatment with the amifostine. He is glad he did it now, almost two years past radiation, he still has some dry mouth, but not near as bad as right after. He was only 37 when he went through radiation and very healthy, except for the cancer. Good luck, I hope you can take the amifostine. Julie