My wife has had two infusions of Keytruda. She had a gingival squamous cell carcinoma resected in 2019 with clear margins and no follow-up chemo or immunotherapy. Had course of radiation. Had recurrence in early 2020. Surgery postponed due to covid, but on the day before she was going to start chemo, they started doing surgeries again...and she was at the top of list. Had her jaw removed, 43 nodes all negative, margins clear but lympho-vascular infiltration. Within 3 months, had a dermal metastasis to the area just behind her ear and a recurrence near the TM joint extending to her orbital bone.

Started Keytruda a month ago. Had 2nd course last week. Her pain seems to be worsened a couple of days after the treatments. I figure this may be a reaction to her immune system attacking her tumors. Is this a common reaction? Get better with more treatment?