Yes, there are many studies all over the world and no, it isn't as simple as throwing a blood thinner at it. Doctors just let people die because, much like aging, once the blood vessels are shot, there really is not a lot of options.

Keep in mind, blood vessels, like the digestive tract, have smooth muscles. These muscles, along with the heart, help move the blood and valves keep it from going backwards. Veins send out oxygenated blood through arteries and return blood for oxygenation via veins.

I have posted this a few times but the treatment most successful for this, radiation induced fibrosis and osteoradinecrosis, worldwide, has consisted of Pentoxyphylline/alpha Tocopherol with HBOT and to a lesser degree, a bisphosphonate called Clodronate, which is not available here.

Pentoxyphylline is a vasodilator, while alpha Tocopherol is a very old form of vitamin E, which is a blood thinner, among other things. Pentoxyphylline has an unusual characteristic of forcing blood into areas blood doesnt't flow, unlike HBOT that actually creates new capillaries. The bisphosohonate removes the calcium.

As soon as the weather breaks, I will do another round of Etidronate, a bisphosphonate. I chose this because it is one of the few that does not contain nitrogen, which I believe can trigger the nitric oxide cycle that begins the oxidative stress cycle from trauma. I hope to combine this with some HBOT.

For whatever reason, these studies are being done in Europe but not a lot of activity here, most likely because of funding, combined with the random nature of how all this presents.

I believe I understand why some previous studies weren't successful or better, what combinations of activity and medication that is most effective. I have reduced the recommended dose by 1/3 (2 times/day vs 3) mostly because the combination with bisphophonate gets pretty brutal. I worked through it, but I think most people would stop when it gets difficult, as there may be less progression or they may still be treatable, in the eyes of the doctors. I'm just running out of time.

SCC Stage IV, BOT, T2N2bM0
Cisplatin/5FU x 3, 40 days radiation
Diagnosis 07/21/03 tx completed 10/08/03
Post Radiation Lower Motor Neuron Syndrome 3/08.
Cervical Spinal Stenosis 01/11
Cervical Myelitis 09/12
Thoracic Paraplegia 10/12
Dysautonomia 11/12
Hospice care 09/12-01/13.
COPD 01/14
Intermittent CHF 6/15
Feeding tube NPO 03/16
VFI 12/2016
ORN 12/2017
Cardiac Event 06/2018
Bilateral VFI 01/2021
Thoracotomy Bilobectomy 01/2022
Bilateral VFI 05/2022
Total Laryngectomy 01/2023