Don,

1. I woudn't do it again. There are other less toxic options with the same outcome for HPV oropharynx cancer, and just may be an overkill, pun intended. My response was different, beyond brutal, but my cancer was gone just from the 5 days TPF, that almost killed me, which I only was able to later find out after 9 months. Laying in a hospital bed for 6 months, in isolation, being told you're too sick to have anything done, let alone not be able to walk, was the worst. As such, that's why my cancer was able to spread, had more recurrences, 8, but each their own. One day I'll write about my experience.

2. HPV-16 is the high risk HPV variant, which is the type mostly associated with HPV oropharyngeal cancer. To a lesser extent, HPV 18. There are about 150 HPV types, some simple warts, and about 15 are high risk that can go on to cause cancer, in some, like ours.

http://oralcancernews.org/wp/study-...ncer-patients-to-vary-depending-on-site/

3. Yes, being HPV-16 positive, p16 positive ( tumor suppressor gene) in oropharyngeal cancer is good, but with other cancers being p16 positive is a negative factor, and reduces risk of survival.

4. Yes, HPV negative is "usually" associated with smoking , drinking, with poorer outcome. Some HPV seems to respond like smoking, drinking caused does, more aggressive.

http://www.news-medical.net/news/20...-positive-and-HPV-negative-patients.aspx




I probably confused it more. The more I know the less I understand too smile


10/09 T1N2bM0 Tonsil
11/09 Taxo Cisp 5-FU, 6 Months Hosp
01/11 35 IMRT 70Gy 7 Wks
06/11 30 HBO
08/11 RND PNI
06/12 SND PNI LVI
08/12 RND Pec Flap IORT 12 Gy
10/12 25 IMRT 50Gy 6 Wks Taxo Erbitux
10/13 SND
10/13 TBO/Angiograph
10/13 RND Carotid Remove IORT 10Gy PNI
12/13 25 Protons 50Gy 6 Wks Carbo
11/14 All Teeth Extract 30 HBO
03/15 Sequestromy Buccal Flap ORN
09/16 Mandibulectomy Fib Flap Sternotomy
04/17 Regraft hypergranulation Donor Site
06/17 Heart Attack Stent
02/19 Finally Cancer Free Took 10 yrs