I know there are a lot of things associated with oral cancer that cause fear and I hate to add one but feel people should be aware of the risk of anaphylaxis (severe allergic response) and cetuximab (Erbitux).

Up until now I have not posted of my husband's oral cancer recurrence and his grim prognosis. Because the cancer had spread to his pulmonary lymphatics, the only course of treatment was chemo for symptom control. The triple cocktail of cisplatin, 5FU and cetuximab was to be used. He was to receive standard antihistamines prior to his infusion.

Yesterday during his first infusion ever of cetuximab he experienced a severe allergic reaction which closed his airway and led to cardiac arrest. It all happened very quickly. He was able to be intubated but only with great difficulty. Given the amount of time he was without circulation, at our request the tube was removed and he died this morning.

A quick internet search reveals that allergic reactions are a well known side effect. Epidemiological data also point to a higher incidence in certain parts of the US and may be related to a history of tick bites. Though in Australia, my husband worked in the bush and regularly came home with tick bites.

A cruel twist to cruel treatment for a cruel disease. I have been blindsided and feel totally unprepared.