My first (of 3) infusions took roughly four hours. Big bag of fluids, bag of anti- nausea and bag of cisplatin simultaneously, then another bag of fluids. Had a little discomfort during cisplatin and they slowed things down a bit. A few hours later the vein in my right arm was hard as a rock from the IV point to my armpit. I thought I was a tough guy and gave it a go with no port. The vein was back to normal in time for round two. They overreacted and this one took 7 hours. Last one was the happy medium with no discomfort or hard veins.