Thanks Calhoun. Tough decisions. No matter which one there will still be toxicities, which also go by the dosage amount, rate of infusion, and duration. Maybe they can slow the rate of infusion? I posted an article with Weekly vs Large 3 bag Cisplatin, if you use search, noting the toxicities reactions, and overall survival etc, and may have been other discussions on other posts. I believe weekly, in this abstract, had higher grade mucocitis than the large doses, 3 bags had higher grade neutropenia. Weekly had bette overall survival. I had Induction chemo, which were large doses, 160mg Cisplatin at once, and one of the 3 chemos, so there was no stopping or time to see of any adverse reactions, which was one draw back. Good luck.