I couldn't have my 2nd big bag of Cisplatin today because my creatinine is still too high (172) and my GFR too low (31). If I improve by next Monday, I'll start low weekly doses of Cisplatin for the remainder of my treatment. I don't have a history of kidney problems, but it seems the first big bag hit mine hard.

Anyone else have a similar interruption/change occur? What are the side effects like for weekly Cisplatin?

Also wondering about the efficacy of weekly v. 3 mega-doses -- If my MO thought it was as good or better he would have started me with weekly chemo, so I'm fretting that we're defaulting to a less proven/effective plan. I looked around and only found one small clinical trial comparing the two for HNC, does anyone know of any data? Looking at folks' signatures I see that many receive weekly chemo, so I'm guessing/hoping it's backed by solid science that some institutions may have embraced ahead of others.

Thanks for any info and suggestions, you all are so generous with your support and help --

M