I posted some data comparing the two, and are basically comparable, but both have sides effects more or less than the other. If your kidneys are compromised, you don't have much choice, which weekly I believe has less hardship then the 3 bag method. My creatine is 2.85, and GFR is 22, probably my baseline now because of chemo. Was 7.5 and 8 when I had acute renal failure in May, and almost went on dialysis. If I see the post, I'll attach. Once the kideys are damaged they may not return it normal, but may when chemo is stopped or causation corrected.