It's probably 100% likely you will have some sort of side effect from any chemo or targeted therapy, like Erbitux. To what extent may be different in everyone, and depends on the chemo, the dosage, rate of infusion, duration of infusions, if combined with another chemo and or radiation, general health, age, and comorbidities. I made a link to a study or paper on weekly Cisplatin vs 3 big bag Cisplatin, a few months back. From what I recall, the weekly seemed to have better overall survival, but higher degree of mucocitis than 3 bag, and less effect on kidney function impairment. I'll have to go back to find it.

In addition to baseline hearing test Mr. T mentioned, have a baseline TSH test for the thyroid, the creatine, GFR, for the kidney function, which they do or should every week before infusions, an eye exam, vision test, and testosterone levels.