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| Joined: Dec 2003 Posts: 2,606 Likes: 2 Patient Advocate (old timer, 2000 posts) | Patient Advocate (old timer, 2000 posts) Joined: Dec 2003 Posts: 2,606 Likes: 2 | I think there should be black box warnings on this class of drugs for anyone going through chemo or radiation. Most neurological or neuromuscular issues will be exacerbated. Musculoskeletal issues as well.
I think any MRI's with contrast prior to 2007 or so are highly suspect for fibrosis and vascular constriction and resultant kidney, liver, lung or heart failure. It was believed all fibrosis began with the skin but in 2003 post mortems were performed and the link to organs was established. Vascular constriction with electrolyte imbalance, specifically potassium will cause temporary and potentially permanent peripheral neuropathies. GFR should always be checked prior to using GBCA's. I don't see it being done but I know someone has to be reviewing lab histories before the MRI. The results can be fibrosis of any connective tissue in the body and even broken bones due to weaker connective tissue.
SCC Stage IV, BOT, T2N2bM0 Cisplatin/5FU x 3, 40 days radiation Diagnosis 07/21/03 tx completed 10/08/03 Post Radiation Lower Motor Neuron Syndrome 3/08. Cervical Spinal Stenosis 01/11 Cervical Myelitis 09/12 Thoracic Paraplegia 10/12 Dysautonomia 11/12 Hospice care 09/12-01/13. COPD 01/14 Intermittent CHF 6/15 Feeding tube NPO 03/16 VFI 12/2016 ORN 12/2017 Cardiac Event 06/2018 Bilateral VFI 01/2021 Thoracotomy Bilobectomy 01/2022 Bilateral VFI 05/2022 Total Laryngectomy 01/2023
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