The single dose toxicity side of the study is done. They are now moving to the three dose stage where they do a full dose, then another full dose 30 days later and then a half dose 15 days after that. They would scan at the end of the first 30 days to asses efficacy. If no or little change I can move on to radiation or chemo but will have lost time.

I would now be trying radiation number 4. I may be a candidate for one additional radiation treatment but I think it would only give me a bit more time. They have had some success even this far out but the doctor said it was very, very rare.

Chemo does not seem to have made any huge leaps of late. I would still be buying time but I also have to consider quality of life. The radiation comes with immediate and permanent QOL issues. Chemo comes with immediate QOL issues that could extend my final days but in misery.

At this point I have resigned myself to the idea that this is and end of life scenario. Radiation would make that time miserable. The right chemo (if effective) could give me some extra time with some quality of life but it would have to be with limited side effects. I would rather spend less quality time than more miserable time.

The viral trial is the hail marry play. Plus I can add to the scientific understanding of this line of treatment long after I�m gone. Also, I have an option of last chance chemo or radiation if it fails.

Right now those are the three that are in front of me. I have some time to look around but can say that I have been to a number of CCC�s already. I would only be seeking more hail marry type solutions from trials that might take me. A very small pool of possible choices.