It sounds very much like a drug interaction of some sort. You know your wife better than anyone, you saw the correlation and hey should have listened to you from the outset. The same thing happened to my mom, she was always very sensitive to drugs - when she was hospitalized with a bowel perforation. They switched her meds to a palliative pain med (she had brain mets from lung cancer at the time. When we first went in after her abdominal surgery - she was talkative and joking -withing 12 hrs of changing her meds she became almost non responsive - my step dad noticed immediately the change and suggested it might be the new med - they said no, it's usually well tolerated etc.. We went through two days like this. He said it to them again they still didn't listen then he told them I was a nurse so when I finally told them point blank I want her off it! They stopped immediately. And for them not to give her another med unless she was in pain and asking. Sure enough her entire demeanor changed!!! She became far more lucid etc... I was even able to ask her if she was in pain and she could respond and carry on a conversation though at that time she was gravely ill. drs who think they know everything are dangerous - drs who are threatened when you question them are even more dangerous - it means they have trouble admitting they don't know everything and that's a bad thing! what you did was right. Also I am one of the least prejudice people you will ever meet - I do not see colors I judge the person, however if you are in an industry where you are dealing with the public - particularly if you are in a profession like medicine - you should be abl to speak the primary language CLEARLY - IMHO - remember everyone is different! Just because 9 out of 10 people don't have a reaction... Doesn't mean Linda's not the 1 who does - btw .26% of people having heparin - complain of hallucinations... They did a study! hugs and get some sleep!