Laura, there are some supplements that you need to be careful with as they can help the cancer as well as the healthy cells - vitamin E has been shown to increase the chance of H&N cancer recurring if you take it during or even after therapy. Other supplements may decrease the effectiveness of the therapy itself, as Cheryl mentioned. Make sure you list everything he takes and run it by your team.
However the
HPV determination comes up, remember that part of the outcome rests on how closely the treatment plan is followed, and how healthy the person is to begin with. It sounds like you've got both those points covered! If he is a smoker or smokeless tobacco user, he needs to quit now.
Remember to care for yourself, as well!