So far the only HPV studies that we have said that the HPV virus seems more likely to attack the cells found in the Base of Tongue and Tonsils and similar cells found in the anus, penis and cervix to mention a few.

Brief history, it used to be that the overwhelming likely candidate for OC was a elderly man who sat in a bar and smoked and drank his adult life. Then about 10 years ago we began to identify another group of OC patients who were not smokers, mostly male whose cancer was mostly in those 2 areas and the HPV virus was soon identified as the cause. About 3 years ago studies concluded that the typical HPV positive OC patient was a white male, born after 1948, non smoker, casual drinker, Primary in the BOT or Tonsils, often mets to a node or 2 and college educated. In fact if one presents themselves like this you have a 70+% chance that your Primary will test positive for HPV. The studies also concluded that HPV+ OC responded better to conventional treatments; had a better survival rate and had less of a chance of a recurrence. Then about 3 years ago I started noticing what I will call a 3rd group posting here who were younger still, males and females, non smokers, etc but their Primary was in the forward part of the tongue or oral cavity. They didn't test positive for HPV and their cancers appear to be just as aggressive as tobacco related OC. No cause as of yet has been associated with this 3rd group and the treatment remains fairly uniform for all 3 groups but there is talk of somehow trying to reduce the side effects of the HPV group since it has preliminarily shown a better response to Tx but no studies to my knowledge have been approved towards that end.