knine,
I'm going to get very blunt with you as is my way...but know this is for you're own good and it's done out of love.

First...stop f@ck'n smoking. If you didn't know, it causes cancer.
Second, how many Dr's are going to have to tell you the same thing before you stop beating around the bush and get a biopsy from the site that concerns you? It's the only way to get the definitive answer you obviously need so stop stressing about it and take the bull by the horns already. Anybody on this site will tell you that I'm no fan of most Dr's...but they aren't all f*ck'n worthless and at least one of the four you've seen so far may not have their head up their ass.
I think I speak for many on this site when I say you have no idea what "hopeless" is so let me define it for you. Hopeless is sitting in front of your Ear Nose & Throat Dr who tells you that a biopsy confirms you have cancer, it's inoperable and there are no other options available to you to extend your life. Since you haven't had that experience, you still have hope.
Since you are in Seattle, I will even steer you in the right direction. Call the University Of Washington Medical Center (#6 in the US for Cancer Care and #12 in Head & Neck) and ask for the Otolaryngology dept. Schedule an appt and tell them to biopsy the area you are concerned about. Dr. Neil Futran is the head of that program and literally one of the finest surgeons in the country, if he can't calm your fears I'd suggest seeking a different type of Dr for your head...
Sorry to be so blunt, but panicking and becoming "hopeless" isn't going to help you or get you any answers.
Your welcome by the way.
Eric