#73853 04-29-2008 01:31 PM | Joined: Apr 2008 Posts: 117 Likes: 1 Senior Member (100+ posts) | OP  Senior Member (100+ posts)
Joined: Apr 2008 Posts: 117 Likes: 1 | The first oncologist I saw said he would use Carboplatin as the chemo. The second one said he would use Cisplatin. Any thoughts about this. BTW, I found an review on PubMed that says Cisplatin is better for head and neck cancer. http://www.ncbi.nlm.nih.gov/pubmed/9541678
Squamous cell carcinoma base of tongue. Lymph involvement unclear; staging placed at "2 or 3." Biopsy 4/18/2008. Treatment: IMRT every day for 7 weeks. Cisplaten once a week to sensitize cancer to radiation. Treatment ended 7/16/08. PET/CT shows no more cancer.
| | | | | Joined: May 2007 Posts: 666 "Above & Beyond" Member (500+ posts) | | "Above & Beyond" Member (500+ posts)
Joined: May 2007 Posts: 666 | Quite often they start you out with cisplatin and then depending on side effects switch you over to carboplatin.
M
Partial glossectomy (25%) anterior tongue. 4/6/07/. IMRT start @5/24/07 (3x) Erbitux start/end@ 5/24/07. IMRT wider field (30x) start 6/5/07. Weekly cisplatin (2x30mg/m2), then weekly carbo- (5x180mg/m2). End of Tx 19 July 07.
| | | | | Joined: May 2007 Posts: 622 Likes: 1 "Above & Beyond" Member (500+ posts) | | "Above & Beyond" Member (500+ posts)
Joined: May 2007 Posts: 622 Likes: 1 | If you start to experience tinnitus (ringing in your ears) they will switch you to Carboplatin. Cisplatin can be very toxic to the inner ear.
From what I have read, there is not much difference in the net result by switching.
Kevin
18 YEAR SURVIVOR
SCC Tongue (T3N0M0) diag 06/2006.
No evidence of disease 2010
Another PET 12-2014 pre-HBO, still N.E.D.
�Remember to look up at the stars and not down at your feet. It matters that you don't just give up.�
Stephen Hawking | | | | | Joined: Sep 2006 Posts: 8,311 Senior Patient Advocate Patient Advocate (old timer, 2000 posts) | | Senior Patient Advocate Patient Advocate (old timer, 2000 posts)
Joined: Sep 2006 Posts: 8,311 | I asked my MO why, when I developed hearing losses, he didn't use Carbo in the first place and he said that in his opinion Carbo is just as effective as Cis but without the bad side effects but Cis has been the standard for a longer time and therefore more data is out there. He also said that only a small percentage develop hearing problems (lucky me again). Many treatments also break the dosages up now whereas I had 3 large IV's and now you see 6 weekly bags and perhaps that will minimize the ones damaged even more.
David
Age 58 at Dx, HPV16+ SCC, Stage IV BOT+2 nodes, non smoker, casual drinker, exercise nut, Cisplatin x 3 & concurrent IMRT x 35,(70 Gy), no surgery, no Peg, Tx at Moffitt over Aug 06. Jun 07, back to riding my bike 100 miles a wk. Now doing 12 Spin classes and 60 outdoor miles per wk. Nov 13 completed Hilly Century ride for Cancer, 104 miles, 1st Place in my age group. Apr 2014 & 15, Spun for 9 straight hrs to raise $$ for YMCA's Livestrong Program. Certified Spin Instructor Jun 2014.
| | | | | Joined: May 2007 Posts: 666 "Above & Beyond" Member (500+ posts) | | "Above & Beyond" Member (500+ posts)
Joined: May 2007 Posts: 666 | Getting the chemo weekly i.e. 7 times instead of 3 times a big dosage lowers the acute toxicity and should give more sustained level of drug. However, even so, I developed problems after just one cisplatin infusion (within 4 days)... My RO figured that was just in my head.... no kidding. In any event it got worse after the second infusion and we switched to carboplatin (higher dosage). I too was told that carboplatin is just as effective... which begs the obvious question.... why did we start with it. Cisplatin has been around a lot longer and MO's are more comfortable with it, plus it is also more active (hence the lower dosage compared to carboplatin).
Carboplatin does is lower your white blood count quite dramatically, cisplatin is also myelosuppressive but not as bad.
M
Partial glossectomy (25%) anterior tongue. 4/6/07/. IMRT start @5/24/07 (3x) Erbitux start/end@ 5/24/07. IMRT wider field (30x) start 6/5/07. Weekly cisplatin (2x30mg/m2), then weekly carbo- (5x180mg/m2). End of Tx 19 July 07.
| | | | | Joined: Apr 2005 Posts: 2,676 Patient Advocate (old timer, 2000 posts) | | Patient Advocate (old timer, 2000 posts)
Joined: Apr 2005 Posts: 2,676 | MY husband's Chemo Doc initally suggested Cisplatin at our interview. When we told him that John already had some hearing loss AND some slight palsey, he immediately said that Carboplatin was "as effective" and had fewer side effects so that's what he used. Amy
CGtoJohn:SCC Flr of Mouth.Dx 3\05. Surg.4\05.T3NOMO.IMRTx30. Recur Dx 1\06.Surg 2\06. Chemo: 4 Cycles of Carbo\Taxol:on Erbitux for 7 mo. Lost our battle 2-23-07- But not the will to fight this disease
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