Previous Thread
Next Thread
Print Thread
#53493 05-11-2004 05:45 AM
Joined: Feb 2004
Posts: 162
Brett Offline OP
Gold Member (100+ posts)
OP Offline
Gold Member (100+ posts)

Joined: Feb 2004
Posts: 162
Here's some of the data I have:

Prevention of Second Primary Tumors with Isotretinion (13-cis-retinoic acid) (9/20/1990):

Results: There were no significant differences between the two groups (medication & placebo) in the number of local, regional or distant recurrences of the primary cancers. However, the isotretinion had significantly fewer second primary tumors. After a median follow up of 32 months, only 4% of the isotretinion group had SPT's as compared with 12% of the placebo group.

Conclusions: Daily treatment with high doses of isotretinion is effective in preventing SPT's in patients who have been treated for SCC of the head and neck, although it does not prevent recurrences of the original tumor.

The other studies I have involve more than one agent -- interferon and 13-cis-retinoic acid.

-Brett


Base of Tongue SCC. Stage IV, T1N2bM0. Diagnosed 25 July 2003.
Treated with 6 weeks induction chemo -- Taxol & Carboplatin once a week followed with 30 fractions IMRT, 10 fields per fraction over 6 more weeks. Recurrence October 2005.
Joined: Mar 2002
Posts: 4,918
Likes: 67
OCF Founder
Patient Advocate (old timer, 2000 posts)
Offline
OCF Founder
Patient Advocate (old timer, 2000 posts)

Joined: Mar 2002
Posts: 4,918
Likes: 67
Brett...Please be sure to post the source of the data, where it was published etc. if you wish for it to stay on the board. Also remember that data which is four years old, may be still accurate or may not reflect the most current thinking in all things. This is a field where discoveries and trial results appear on a daily basis. What we knew four years ago may have been now superceded by something different. Posting references allows all to judge for themselves, and reading the original study in it's complete form, to determine if the information is still of value, appropriate for them, something to bring up to their docs etc.


Brian, stage 4 oral cancer survivor. OCF Founder and Director. The first responsibility of a leader is to define reality. The last is to say thank you. In between, the leader is a servant.
Joined: Feb 2004
Posts: 162
Brett Offline OP
Gold Member (100+ posts)
OP Offline
Gold Member (100+ posts)

Joined: Feb 2004
Posts: 162
I was worried about making some sort of mistake in posting this. That information was published in the New England Journal of Medicine 9/29/90 of which I was provided a xerox copy of just the study data. I'm not about to retype the entire document. I'll refrain from this type of post in the future. Please go ahead and kill this thread if you think that is the right thing to do.

-Brett


Base of Tongue SCC. Stage IV, T1N2bM0. Diagnosed 25 July 2003.
Treated with 6 weeks induction chemo -- Taxol & Carboplatin once a week followed with 30 fractions IMRT, 10 fields per fraction over 6 more weeks. Recurrence October 2005.

Link Copied to Clipboard
Top Posters
ChristineB 10,507
davidcpa 8,311
Cheryld 5,264
EzJim 5,260
Brian Hill 4,918
Newest Members
Kpwin, Boost iV Miami, dcrowman, Yuka, monkeytoes
13,361 Registered Users
Forum Statistics
Forums23
Topics18,264
Posts197,178
Members13,362
Most Online1,788
Jan 23rd, 2025
OCF Awards

Great Nonprofit OCF 2023 Charity Navigator OCF Guidestar Charity OCF

Powered by UBB.threads™ PHP Forum Software 7.7.5