#19487 01-31-2006 07:17 AM | Joined: Nov 2002 Posts: 3,552 Patient Advocate (old timer, 2000 posts) |  Patient Advocate (old timer, 2000 posts)
Joined: Nov 2002 Posts: 3,552 | It certainly is indicated for metestatic disease here is a link: http://www.chm.bris.ac.uk/motm/cisplatin/htmlonly/
Gary Allsebrook
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Dx 11/22/02, SCC, 6 x 3 cm Polypoid tumor, rt tonsil, Stage III/IVA, T3N0M0 G1/2
Tx 1/28/03 - 3/19/03, Cisplatin ct x2, IMRT, bilateral, with boost, x35(69.96Gy)
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"You are a mist that appears for a little while and then vanishes" (James 4:14 NIV)
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#19488 01-31-2006 07:46 AM | Joined: Feb 2005 Posts: 2,019 Patient Advocate (old timer, 2000 posts) | | Patient Advocate (old timer, 2000 posts)
Joined: Feb 2005 Posts: 2,019 | Goino, I would need to be at home to look at the articles again to be one hundred percent sure about this but there were two giant studies, published in 2004 in the New England Journal of Medicine, one done in Europe and one in the States, that established that 10-15% effectiveness number. They also looked at outcomes for distant metastasis and I believe they did not find any differentce in that outcome based on whether the patient had received concurrent chemo or not.
It's been a while since I read these articels and I could be recalling wrong--I'm willing to stand corrected by anyone who has either article at hand. Even if I am recalling correctly, all the qualifications go along with this that should go with any null result--perhaps they didn't have enough statistical power to detect an effect there, etc.
Nelie
SCC(T2N0M0) part.glossectomy & neck dissect 2/9/05 & 2/25/05.33 IMRT(66 Gy),2 Cisplatin ended 06/03/05.Stage I breast cancer treated 2/05-11/05.Surgery to remove esophageal stricture 07/06, still having dilatations to keep esophagus open.Dysphagia. "When you're going through hell, keep going"
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#19489 01-31-2006 08:47 AM | Joined: Nov 2002 Posts: 274 Platinum Member (200+ posts) | | Platinum Member (200+ posts)
Joined: Nov 2002 Posts: 274 | Nelie,
I do know if we did, or did not discuss this. I regret not getting a chemo wash with my advanced stage 3, early stage 4 cancer. I did not have SCC, I had adnosquamous cell, and it did not spread through the lymph nodes, it was/is in my blood I have never put much stock in all the numbers you and Gail throw around, as I am not a statistician. I don't doubt you knowledge, just the numbers. I do know cancer pretty well and, additionally, what I regret in my treatment choices. I never got cancer back at my original site and that is not where I am looking for treatment. As for metastasis, Myself, Danny, Dinah had excellent results on our mets by using Chemo. Our study involves getting a few more months and I think it is called palliative care. Not everything discussed on here involves a cure. These are the only 3 people I can think of here, is that too small a study?
Glenn | | |
#19490 01-31-2006 04:48 PM | Joined: Feb 2005 Posts: 2,019 Patient Advocate (old timer, 2000 posts) | | Patient Advocate (old timer, 2000 posts)
Joined: Feb 2005 Posts: 2,019 | Glenn, my comment was not intended to address chemo used for other types of treatment, inclusing palliative care. I tried to be very specific that I was just addressing the use of cisplatin concurrently with radiation as it has become recommended since those studies came out.
I'm also sorry if it sounded like I was telling you what to regret. Of course you have a right to whatever regrets you have about choices you made.
Nelie
SCC(T2N0M0) part.glossectomy & neck dissect 2/9/05 & 2/25/05.33 IMRT(66 Gy),2 Cisplatin ended 06/03/05.Stage I breast cancer treated 2/05-11/05.Surgery to remove esophageal stricture 07/06, still having dilatations to keep esophagus open.Dysphagia. "When you're going through hell, keep going"
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