| | Joined: Jun 2013 Posts: 262 Gold Member (200+ posts) | OP  Gold Member (200+ posts)
Joined: Jun 2013 Posts: 262 | I couldn't have my 2nd big bag of Cisplatin today because my creatinine is still too high (172) and my GFR too low (31). If I improve by next Monday, I'll start low weekly doses of Cisplatin for the remainder of my treatment. I don't have a history of kidney problems, but it seems the first big bag hit mine hard.
Anyone else have a similar interruption/change occur? What are the side effects like for weekly Cisplatin?
Also wondering about the efficacy of weekly v. 3 mega-doses -- If my MO thought it was as good or better he would have started me with weekly chemo, so I'm fretting that we're defaulting to a less proven/effective plan. I looked around and only found one small clinical trial comparing the two for HNC, does anyone know of any data? Looking at folks' signatures I see that many receive weekly chemo, so I'm guessing/hoping it's backed by solid science that some institutions may have embraced ahead of others.
Thanks for any info and suggestions, you all are so generous with your support and help --
M
53
T3N2aM0 HPV+
5/26/13 discovered painless superball-sized lymph node in neck
6/26/13 DX SCC R palatine tonsil
7/16/13 TORS tonsillectomy & selective ND, mets to 2 nodes
9/3/13 Cisplatin and rads begin, tolerated 1.5 of 3 planned chemo doses
10/16/13 Treatment ends
Dec 13 Ulcer appears at surgery site
Jan 17 Biopsy -- no cancer!
Feb 17 CT/PET Scan lights up tonsil bed & nasal cavity, docs say probably inflammation, don't panic, rescan when ulcer subsides
| | | | | Joined: Jul 2012 Posts: 3,267 Likes: 4 Patient Advocate (old timer, 2000 posts) | | Patient Advocate (old timer, 2000 posts)
Joined: Jul 2012 Posts: 3,267 Likes: 4 | I posted some data comparing the two, and are basically comparable, but both have sides effects more or less than the other. If your kidneys are compromised, you don't have much choice, which weekly I believe has less hardship then the 3 bag method. My creatine is 2.85, and GFR is 22, probably my baseline now because of chemo. Was 7.5 and 8 when I had acute renal failure in May, and almost went on dialysis. If I see the post, I'll attach. Once the kideys are damaged they may not return it normal, but may when chemo is stopped or causation corrected.
10/09 T1N2bM0 Tonsil
11/09 Taxo Cisp 5-FU, 6 Months Hosp
01/11 35 IMRT 70Gy 7 Wks
06/11 30 HBO
08/11 RND PNI
06/12 SND PNI LVI
08/12 RND Pec Flap IORT 12 Gy
10/12 25 IMRT 50Gy 6 Wks Taxo Erbitux
10/13 SND
10/13 TBO/Angiograph
10/13 RND Carotid Remove IORT 10Gy PNI
12/13 25 Protons 50Gy 6 Wks Carbo
11/14 All Teeth Extract 30 HBO
03/15 Sequestromy Buccal Flap ORN
09/16 Mandibulectomy Fib Flap Sternotomy
04/17 Regraft hypergranulation Donor Site
06/17 Heart Attack Stent
02/19 Finally Cancer Free Took 10 yrs
| | | | | Joined: Jul 2011 Posts: 945 "Above & Beyond" Member (500+ posts) | | "Above & Beyond" Member (500+ posts)
Joined: Jul 2011 Posts: 945 | Please don't fret too much, Mamacita. Your primary therapy was surgery, and your chemo-radiation is the followup. There are variety of studies showing a variety of results: we don't have a really big study comparing the big bag vs weekly with HPV positive tumors. The doctors and statistician can beat the available data, but I'm afraid you will need a time machine to get a more definitive answer. From what I have read, keeping the radiation on schedule (especially early on) should be your primary objective. Best wishes, Maria
CG to husband - SCC Tonsil T1N2M0 HPV+ Never Smoker
First symptoms 7/2010, DX 12/2010
TX 40 IRMT (1.8 gy) + 10 Cetuximab
PET Scans 6/2011 + 3/2012 clear, 5 year physical exam clear; chest CT's clear of cancer. On thyroid pills. Life is good.
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